After 120 min, we observed significant (p < 0.05) decrease in body temperatures in animals treated with Cc, Og, MiL, MiB and Cs. After 240 min, we observed that Cc exhibited the best activity with pyrexia inhibition of 95 %, followed by MiL (90), MiB (88), Og (85) and Cs (82), comparable to the standard drug, paracetamol (100). Here, CXCR1 is linked to Fever.