Western blotting results showed that with the increase of concentrations of 3BP the expression of MCT1, MCT2 and HKIIwas reduced, in turn MCT2 expression did not change basically (Fig. 2c), The results indicated the 3BP transporters into colon cancer cells through MCTs, influencing the expression of HKII. This evidence concerns the gene HK2 and colonic neoplasm.