Inhibition of both the PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways have recently displayed promising treatment response to HCC7 which has also prevent HUVEC-C3 differentiation in the co-culture model, suggesting the potential of the co-culture model as a screening platform for HCC. This evidence concerns the gene MAP2K7 and hepatocellular carcinoma.