Previous results from our laboratory suggested that ectopic LBR expression in suprabasal cells of the epidermis may contribute to the impaired skin development phenotype in mouse expressing the LMNA c.1824C>T mutation (a mutation that has been associated with two different laminopathies, Restrictive Dermopathy and HGPS) during embryonic and early postnatal skin development [20]. This evidence concerns the gene LBR and Hutchinson-Gilford progeria syndrome.