PKD1 and autosomal dominant polycystic kidney disease: Autosomal dominant polycystic kidney disease (ADPKD), a genetically heterogeneous disease in which 2 genes are involved, PKD1 (chromosome16p13.3) and PKD2 (chromosome 4q21-23)[1], is the fourth commonest cause (approximate 10%) of all cases of end stage renal disease[2].Approximate 50% of ADPKD patients ultimately require dialysis or renal transplantation by the age of 60[3], with a loss of 4.4–5.9 ml/min in the GFR[4].