For example, PLEC, ANXA10, EHF, SLC4A, and CUL4A are expressed at high levels in MDA-MB-231 relative to MCF-7 cells, and MAGED1, SYK, and EPCAM are expressed at higher levels in triple-negative cancer tissues relative to non-invasive control tissues (Fig. 4D). The gene discussed is CUL4A; the disease is cancer.