To externally validate the association between high leptin and OB-Rb levels and poor outcome, we downloaded the TCGA serous ovarian cancer database (including mutations, putative copy-number alterations from GISTIC, mRNA expression data and protein/phospho-protein levels) and analyzed the data using the cBioPortal tools [51, 52]. Here, RB1 is linked to ovarian serous adenocarcinoma.