AKT1 and ovarian cancer: We also found that ovarian cancers with high mRNA LEP/LEPR levels exhibit multiple protein changes (either in level of expression or phosphorylation status) involving different signaling pathways, some of which are directly related to the response to cytokines, growth factors and hypoxia stimuli (e.g., JAK, STAT3, HIF1α, SNX), cell cycle regulation, cell growth and differentiation, the stress response, apoptosis, lipoprotein metabolism and oncogenic transformation (e.g., MAPK, AKT, PTPN, AMPK; see Supplementary Figure 6).