Interestingly, OB-Rb expression tended to increase again in the ascites (Figure 2C) and metastatic lesions (either at mesothelium or omentum) in high-grade serous lesions, with a score pattern similar to that observed in type I ovarian cancers (lower right images in the serous panel in Figure 2A and Figure 2B). The gene discussed is RB1; the disease is ovarian cancer.