In addition, cytoskeleton remodeling which is essential for cell movement and growth, is also altered in PDAC tumor cells as reflected by the alteration of axonal guidance, actin cytoskeleton, virus-entry via endocytosis, clathrin-mediated endocytosis, macropinocytosis signaling, as well as signaling pathways activated by the Rho family of GTPases [28-30, 32]; of note, many of such processes had been previously described to be altered in PDAC [27, 29, 30, 33]. This evidence concerns the gene RHO and neoplasm.