ROC curve analysis based on those mRNA and miRNA transcripts differentially expressed in PDAC vs. non-tumoral pancreatic tissues, revealed a combination of just 5 genes (S100A11, GPR137B, SULF1, POSTN and miR-155) that allowed accurate classification (32/32 samples correctly classified) of PDAC tumor vs. non-tumoral pancreatic tissues (Table 2). This evidence concerns the gene GPR137B and neoplasm.