RSPO3 and neoplasm: In contrast, those miRNA genes which were overexpressed in GEP-B tumors included the miR-1180, miR-362-5p and the miR-423, all of which promote tumor cell proliferation and invasion through e.g. the BMP binding endothelial regulator (BMPER), the FYVE Rho GEF and PH domain containing 1 (FGD1) and the R-spondin 3 (RSPO3) genes.