Additionally, GEP-A tumors also showed an altered expression of genes involved in cell proliferation, angiogenesis, cell motility, invasion and tumor progression (e.g. genes involved in the MSP-RON, actin nucleation by the AR-WASP complex and by the Rho, Rac, PAK, Cdc42, integrin, ERK/MAPK, Paxilin, FAK, NF-KB, calpain protease and glioma tumor invasiveness pathways [28, 38-48], among other genes [31, 49, 50]), would confer a highly-aggressive phenotype to GEP-A tumor cells. This evidence concerns the gene RHO and central nervous system cancer.