RHO and neoplasm: Thus, the most top-ranked altered networks (e.g.: axonal guidance, inhibition of matrix metalloproteinases, semaphorin, epithelial adherent junction and Rho family of GTPases signaling pathways) are directly involved in cell-cell and cell-matrix adhesion, extracellular matrix degradation and tissue remodeling, angiogenesis, tumor cell migration and invasiveness [28-31].