TRPV1 and neuroblastoma: In this context, we considered the possible involvement of L-type voltage-gated Ca2+ channels or TRPV1 (transient receptor potential vanilloid 1) channels, which have been shown to mediate the Ca2+ influx responsible for glutamate-induced apoptosis in VSC 4.1 cell line (a motor neuron and neuroblastoma hybrid cell line) [51] and capsaicin-induced apoptosis in glioma cells [52], respectively.