Whereas MYCN amplification is a powerful prognostic marker in NB, a typical MYCN gene signature is found in both MYCN amplified NB and in a subset of MYCN non-amplified NB having post-transcriptionally stabilized N-myc protein or amplified MYC. This signature was more powerful, as a prognostic marker, than MYCN amplification [5]. The gene discussed is MYC; the disease is neuroblastoma.