This is the case for TP53, mutated in approximately 60% of sporadic lung, ovary, bladder, intestine, and head and neck cancers, whose frequency exhibits little or no increase in the Li Fraumeni syndrome [50–52], or for ATM itself, frequently mutated in sporadic colon cancer (cancer.sanger.ac.uk/cancergenome/projects/cosmic/), not a typical hallmark of AT [7]. Here, ATM is linked to Li-Fraumeni syndrome.