In cellular systems, mutant AKT1-E17K promotes anchorage-dependent and -independent proliferation, increases the ability to migrate and invade through reconstituted basal membrane as well as to survive and duplicate in stress conditions in vitro, leading to the emergence of a cell population endowed with the capability to form aggressive, undifferentiated tumours at high efficiency that are able to disseminate and colonize lungs in mice. The gene discussed is AKT1; the disease is neoplasm.