Tumours were classified as poorly differentiated squamous cell carcinoma in 4 cases and poorly differentiated adenocarcinoma in 5 cases (data not shown) with marked activation of AKT signalling as determined by immunoblot for pAKT (S473) and pGSK3α/β (9/21) (Figure 3D). The gene discussed is AKT1; the disease is squamous cell carcinoma.