AKT1 and non-small cell lung carcinoma: In summary, the conclusion drawn by the experiments reported here is that mutant AKT1-E17K is an oncogene that can transform human immortalized lung epithelial cells and that the relocalization of the cyclin-dependent kinase inhibitor p27 is a key mediator of the oncogenic activity exerted by the E17K mutation of AKT1, with cytoplasmic relocalization of p27 being predictive of poorer prognosis in NSCLC patients.