These results are in agreement with recent studies showing that urethane-induced lung tumors showed reduced nuclear/cytoplasmic ratio of p27 protein and increased T198-phosphorylated p27 in the cytoplasmic pool, and that AKT inhibition in murine lung tumour cell lines and in tumour-bearing mice led to a reduction in p27 T198 phosphorylation and its redistribution to the nucleus [62]. This evidence concerns the gene AKT1 and neoplasm.