PTEN and extraskeletal myxoid chondrosarcoma: As alternative hits in the PI3K/AKT signaling pathway, one case of EMC without PIK3CA mutation exhibited a mutation in AKT1 in codon 17, a well-known and often described mutation [21, 22], and one case of SDC without PIK3CA mutation carried a PTEN mutation in codon 252, another known mutation [23, 24].