In contrast, ERα protein and mRNA as well as PR mRNA were significantly reduced (Figure 5a and f), all of which are associated with poor prognosis in human breast cancers.30 Notably, these characteristics of advanced tumorigenic mammary lesions were reversed by FTY720 administration to the HFD-fed transgenic mice (Figure 5b). The gene discussed is PGR; the disease is breast carcinoma.