DIANA-miRPath analysis identifies gap junction signaling as the top-ranked miR-206-regulated pathway (P=2.58 × 10−6).60 Among the targeted gap junction proteins, CX43 is a validated miR-206-regulated transcript, as previously shown in muscle cells.38, 61 CX43 is deficient in human breast tumor cells and MaCSCs, and may exert a tumor-suppressor role.62, 63, 64, 65, 66, 67, 68. Here, GJA1 is linked to neoplasm.