Because previous reports have shown that PHB2 has a putative nuclear localization signal (NLS) at 86-RPRK-89 [4, 13], we hypothesized that PHB2 is translocated to the nucleus via its interaction with Karyopherin-alpha family (KPNAs, importin-alpha) proteins in breast cancer cells. This evidence concerns the gene PHB2 and breast carcinoma.