TGFB1 and Hypertension: Moreover, the therapeutic use of losartan goes beyond hypertension: Losartan is used for its protective effect against dilation in aortic aneurysm [41–43] and proteinuria in glomerulonephritis [44, 45]; it is proposed to be anti-fibrotic, with some studies supporting the hypothesis of a cross-talk between AT1R and TGF-β1 [46].