30 The tegument pp65 is one of the candidate antigens for a HCMV vaccine, because a substantial fraction of CD8+ T cells of CMV-seropositive individuals is directed against epitopes of this viral protein.31,32 During the late phase of the HCMV infection cycle, pp65 is highly expressed in infected cells33 and is the most abundant protein in HCMV virions.34 The gene discussed is CD8A; the disease is cytomegalovirus infection.