FGFR1 and metastatic melanoma: FGFR1 signaling has been implicated in melanoma progression [43]; introduction of antisense oligonucleotides targeted toward FGFR1 into metastatic cell lines results in decreased proliferation and signs of differentiation [44, 45]; and injection of an antisense FGFR1 construct into primary and metastatic melanomas grown in nude mice results in inhibition of tumor growth and induction of apoptosis [46, 47].