TUBA1A and microcephaly: Mutations of NDE1, which encodes a protein that binds dynein and functions in centrosome duplication, as well as the TUBA1A mutations mentioned above, cause microcephaly with a simplified gyral pattern, agenesis of the corpus callosum, and cerebellar hypoplasia (Alkuraya et al., 2011; Bakircioglu et al., 2011).