RELN and lissencephaly spectrum disorders: Among them, frontal predominant mild lissencephaly (diffuse pachygyria) with severe hippocampal and cerebellar hypoplasia or Reelin-type lissencephaly is caused by mutation of either RELN or VLDLR and shows autosomal recessive inheritance (Hong et al., 2000; Boycott et al., 2005).