KRAS and colorectal carcinoma: When HCT116 colorectal carcinoma cells, which express KRas with a G13D mutation, were intoxicated with PA in combination with LFNDUF5Vv (Fig. 4c) or LFNDUF5Ah (Supplementary Fig. 8), significant cell morphological changes were observed and Ras was undetectable by western blotting.