Down-regulation of RECK has been shown to correlate with enhanced tumor invasion, angiogenesis, and metastasis (Noda and Takahashi, 2007), and Reck−/− mouse embryos die in utero at around E10.5 with prominent vascular defects including vessel dilation, hemorrhaging, and arrested development of the primary vascular plexus (Oh et al., 2001; Chandana et al., 2010). This evidence concerns the gene RECK and neoplasm.