PTEN and neoplasm: In particular, genes in bicluster × may be the central nodes from which a cascade of biological events can be triggered or deactivated, depending on the genes and miRNAs that are considered in bicluster Y. Indeed, bicluster × includes key genes (i.e., TGFBR2, BMPR2, SMAD and PTEN) of two related, crucial signaling pathways with antagonistic functions: the TGF-β signaling (tumour suppression) and the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/Akt) signaling (oncogenic unction).