Quantitative RT-PCRs showed that differentiation of CLL B-cells into ASCs induces significant downregulation of LEF1 (7.4-fold), TCL1 (8.2-fold), ROR1 (8-fold), TNFRSF13B/TACI (9.8-fold) and FMOD (8.1-fold) (Figure 4A). The gene discussed is TCL1A; the disease is B-cell chronic lymphocytic leukemia.