Gene expression profiling has been used to characterize CLL-cells and identified several genes whose expression differs between CLL B-cells and normal B-cells including lymphoid enhancer-binding factor 1 (LEF1), receptor tyrosine kinase-like orphan receptor 1 (ROR1), fibromodulin (FMOD), T-cell leukemia/lymphoma 1 (TCL1), Ataxin (ATXN1), early B-cell factor 1 (EBF1) and p27 [5–10] (see also the open web ATLAS (http://amazonia.transcriptome.eu/index.php?zone=Hematology-CLL). Here, ROR1 is linked to B-cell chronic lymphocytic leukemia.