The same exome sequencing studies also found evidence of enrichment for rare disruptive and de novo point mutations among targets of fragile X mental retardation protein (FMRP) (Darnell et al., 2011), a finding that has also been reported for CNVs in a large schizophrenia case-control study (Szatkiewicz et al., 2014). The gene discussed is FMR1; the disease is schizophrenia.