To assess the suitability of Hu-PBL mice as a reservoir to expand and recover human anti-GBM B cells from patients, NSG mice were injected with PBL isolated from two patients (GP01 and GP02) with active anti-GBM glomerulonephritis and detectable circulating anti-alpha3(IV)NC1 antibodies (n = 4 mice, two each with PBL from a patient) or from a healthy donor (n = 3 mice). The gene discussed is COL18A1; the disease is glioblastoma.