Mean plasma concentrations were 5,374.80 ± 4,709.71 and 1,164.56 ± 1,086.03 μg/ml, human IgG, and 92.96 ± 25.45 and 77.44 ± 16.60 μg/ml, human IgM, for nephritis- and healthy donor-derived Hu-PBL mice, respectively. This evidence concerns the gene CD40LG and nephritis.