There was no difference between LST-adenoma and Ip-adenoma in expression of the other proteins, AKT1, MTA2, and ERBB2. We did not get meaningful immunohistochemical staining patterns for the AKT1 and ERBB2 proteins but the MTA2 protein was found to be up-regulated in both LST-Adenoma and Ip-Adenoma compared to normal mucosa. This evidence concerns the gene AKT1 and adenoma.