Using CMV-cre adenoviruses to activate K-RasG12D expression and deplete Lmo4 expression, we targeted all cell types in the lung, including alveolar type II cells that are the predominant cell of origin in K-RasG12D-induced adenocarcinoma [40, 49] but do not express Lmo4. Here, LMO4 is linked to adenocarcinoma.