We assume that Tumor Necrosis Factor α decays naturally at a rate proportional to its concentration and is secreted solely by effector CD8 + T cells in the tumor at a rate that includes both autocrine and constitutive production terms: \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$\left (k_{c2}\frac {\text {TNF}{\alpha }}{k_{2}+\text {TNF}{\alpha }}+k_{3}\right)T_{E3}$\end{document}kc2TNFαk2+TNFα+k3TE3. Here, CD8A is linked to neoplasm.