In exploring the impact of multiple vaccinations, our model indicates that increasing the dose of adenovirus vaccination, the time period between successive adenovirus vaccinations, or the number of adenovirus vaccinations results in a prolonged lifespan of effector CD8 + T cells in all three compartments and extended length of secretion of the cytokines IFNG and TNF α within the tumor microenvironment. The gene discussed is IFNG; the disease is neoplasm.