TCF4 and mantle cell lymphoma: On the other hand, chemical inhibitors of β-catenin-TCF4 interaction, CCT036477, iCRT14, and PKF118-310, effectively decreased the percentage of MCL-ICs from 1 % in buffer control to 0.35, 0.68, and 0.44 %, respectively (Fig. 4a) and induced apoptosis of MCL cells (Additional file 2: Figure S2).