A recent study showed that cobble stone area-forming cells (CAFCs) that developed from MCL co-cultured with human mesenchymal stem cells (hMSCs) are the morphologic equivalent of MCL-ICs with the CD34-CD3-CD45+CD19-CD133+ marker phenotype and manifested their tumor-initiating capacity in NOD/SCID mice [26]. Here, PROM1 is linked to mantle cell lymphoma.