BMP-6 and BMP-9 signals through the type 1 receptor ALK2 in myeloma cells, whereas BMP-2 and BMP-4 do not signal in cells that express ALK2, but lack ALK3 and ALK6, as is the case for the INA-6 myeloma cell line [12,13,15,16]. Here, GDF2 is linked to plasma cell myeloma.