The data, obtained from human histocytic lymphoma U937 cells, indicated that H2O2 and ·OH could activate PI3K-Akt and PLC-Ras-Raf-ERK signaling pathways [78], whereas Xu and Zhang discovered that saturated HS decreased LPS-induced ERK phosphorylation in a rat model of acute liver dysfunction [79]. This evidence concerns the gene HSPG2 and Decreased liver function.