Furthermore, because increased plasma content of sJAM-C was associated with trauma-induced organ failure and also elevated in serum or synovial fluid from rheumatoid arthritis, psoriatic arthritis, osteoarthritis, and systemic sclerosis patients (Rabquer et al., 2010; Manetti et al., 2013), we propose that sJAM-C might be a useful vascular-derived biomarker for assessing the extent of a systemic inflammatory response. The gene discussed is JAM3; the disease is osteoarthritis.