Our findings, together with the reported elevated plasma content of LTB4, as well as NE activity, found in trauma patients that progress to ARDS (Donnelly et al., 1995; Auner et al., 2012), suggest that similar mechanisms (i.e., LTB4-dependent NE cleavage of EC JAM-C) could be taking place following trauma. Here, JAM3 is linked to acute respiratory distress syndrome.