These changes were coinciding with the down-regulation of Th2 cytokines (IL-5 and IL-13) and ECP by both dexamethasone and clarithromycin in eosinophilic polyp, indicating that beyond its well-known suppression on neutrophilic inflammation [15, 21], macrolides may also possess an inhibitory effect on the Th2-dominated eosinophilic inflammation as glucocorticoids. The gene discussed is RNASE3; the disease is inflammatory response.