In addition, both dexamethasone and clarithromycin inhibited the mRNA expression of eosinophilic cationic protein (ECP) (Fig. 8a) in sinonasal mucosa from CRSsNP and eosinophilic CRSwNP, but not in those from non-eosinophilic CRSwNP. Here, RNASE3 is linked to chronic rhinosinusitis without nasal polyps.