The OX40L/PD-L1+ lesional DCs likely under the influence of TSLP in eosinophilic CRSwNP can prime Th2 cells, whereas the low OX40L/PD-L1-expressing lesional DCs with a possible influence by osteopontin in non-eosinophilic CRSwNP primarily induce Th1/Th17 cells [11]. The gene discussed is SPP1; the disease is chronic rhinosinusitis with nasal polyps.