SETX and nervous system disorder: Genes that encode SMN [92–94], ATXN2 [95, 96], senataxin (ALS4) [97], angiogenin (ANG) [98, 99], ewing sarcoma protein (EWS) [100, 101], heterogeneous nuclear ribonucleoproteins (hnRNPA2B1 and hnRNPA1) [39], TATA-binding protein-associated factor 15 (TAF15) [100, 102, 103] along with previously discussed FUS [6] and TDP-43 [7], have functions in post-transcriptional regulation of RNA and mutations in these genes cause motor neuron degeneration and other neurological disorders (Table 1).