For instance, D. melanogaster [132], C. elegans [133], and R. norvegicus [134], models that overexpress ALS-FUS mutations causes motor defects in these models, although it is unclear why overexpression of wild-type FUS in these models has little toxicity given that ALS-FUS 3′UTR mutations cause an increase in FUS expression [130]. This evidence concerns the gene FUS and amyotrophic lateral sclerosis.