EGFR and non-small cell lung carcinoma: Taguchi [26] and Wu [27] used MALDI-TOF-MS to analyze serum and plasma from NSCLC patients; they observed subtle differences in serum/plasma peptides/proteins between two subgroups that experienced significantly different EGFR-TKI efficacies and developed classification algorithms using differential peptides/proteins to predict the efficacy of EGFR-TKI in NSCLC patients.