The SM and DN memory B cell subsets had high expression of Ki-67 during the depleted state as compared to the healthy controls (SM %Ki67+ RA depleted 63.5±4.7% vs. HC 23.0±6.1, p = 0.0017 and DN %Ki67+ RA depleted 39.86±8.1% vs. HC 22.3±4.2, p = 0.05) (mean±SEM) (Fig 3A and 3B). This evidence concerns the gene MKI67 and rheumatoid arthritis.