81 LHON patients carried one of the three common mtDNA point mutations (11778/ND4, 3460/ND1 and 14484/ND6) and 9 carried rare mtDNA mutations (3733/ND1, 14482/ND6, 3890/ND1 and 14495/ND6) [25, 26]. This evidence concerns the gene MT-ND6 and Leber hereditary optic neuropathy.