MTOR and gastroesophageal reflux disease: The phospho-mTOR was considered ‘negative’ i.e., cytoplasmic membranous staining was undetected, or merely observed in a few cells; The latter was found in 10 cases of pill-induced esophagitis, 9 cases of reflux esophagitis and 5 cases of the control group, respectively (S1 Fig).