HIF1A and neoplasm: HIF-1α is a key transcription factor that activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factors (VEGFs) and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia, as well as promoting tumor invasion and metastasis and resistance to therapy [5,6,7,8].