It would be interesting to monitor TEP1 allele exchange also in other African regions where assortative mating was shown to occasionally break down [6] and to assess whether introgressed resistant-alleles increase in frequency in A. gambiae: this could enhance the immune responsiveness of this species and, thus, its ability to compete with A. coluzzii in permanent larval sites, with potential repercussions on vector ecology, distribution and, eventually, malaria transmission especially in those areas where larval habitats are strongly segregated. The gene discussed is TEP1; the disease is malaria.