To confirm and further explore this conclusion, we directly induced the expression of mutant KRAS or mutant EGFR in established lines of human lung adenocarcinoma cells known to be driven by either mutant EGFR (PC9 cells; in-frame deletion in exon 19) or by mutant KRAS (H358 cells; G12C) (Arao et al., 2004; Sunaga et al., 2011). This evidence concerns the gene KRAS and lung adenocarcinoma.