In addition, patients with Mayo stage 1 disease and OPG levels >8 pmol/l had a very short survival (12 versus >60 months, P=0.012; Figure 4a), while OPG level >16.3 pmol/l (75th quartile) further dissected Mayo stages 2 and 3 AL patients (Figures 4b and c). The gene discussed is TNFRSF11B; the disease is axial length measurement.