In our study, no other bone marker correlated with OS; in contrast to MM where several markers of bone remodeling are associated with OS, that is, CTX,20 NTX,16 sRANKL/OPG ratio18 or macrophage inflammatory protein one alpha.21 Cardiac involvement is considered as the most adverse prognostic factor in patients with AL,23 and the cardiac biomarkers NT-proBNP and troponins are the most important prognostic factors for OS.22 During the past decade, OPG has been implicated in the pathogenesis of heart failure of different etiologies. This evidence concerns the gene CYP27A1 and heart failure.