It has been previously reported that the MDMs express both EAAT1 and EAAT2 and are capable of taking up extracellular glutamate.33 Even though both EAATs in MDMs are decreased in gene expression after glioblastoma exposure, the protein levels might reflect different expression patterns as it had been seen that there were non-similar trends in the gene and protein expressions of EAATs in MDMs after HIV infection.22 Therefore, this decrease in gene expression could be a response to the overexpression of EAAT1 and EAAT2 protein in MDMs. This evidence concerns the gene SLC1A3 and HIV infectious disease.