TMC6 and cystic fibrosis: Among 572 children with lung function data beyond age 7 years, an age at which lung function studies are considered reliable, the presence of one or more CAV2 rs8940 derived alleles was associated with a 5.5 percentile point increase in lung function (p = 0.001) (Fig 3A), while presence of one or more TMC6 rs34712518 alleles was associated with an 8.0 percentile point decrease in CF-specific FEV1 (p = 0.01) (Fig 3B).