Overall colitis clinical score was determined at 10 ± 1.8 for WT mice (with 12 being the maximal possible score) and 0.6 ± 0.7 for Iqgap2-/- mice, indicating severe colitis in WT and its absence in Iqgap2-/- mice (Fig 2E). Here, IQGAP2 is linked to colitis.