Mice lacking both Iqgap1 and Iqgap2 display relative protection against hepatocellular carcinoma (HCC) and longer survival compared to Iqgap2-/- mice, implying that at least in the liver IQGAP1 antagonizes activity of IQGAP2 [6]. Here, IQGAP2 is linked to hepatocellular carcinoma.