CBCs of Iqgap2-/- mice (Fig 5B), IQGAP2 protein expression pattern observed in human colitis biopsy specimens (Fig 6) and data on the conditional deletion of Rac1 in mouse neutrophils and macrophages [38] suggest that the neutrophil/macrophage axis may be the predominant one in IQGAP2’s pro-inflammatory function. Here, RAC1 is linked to colitis.