Our results suggesting that the A allele of rs1342387(G/A) protects against colorectal cancer at least in Asians is consistent with a previous report that the A allele is associated with higher serum levels of adiponectin [32], and serum adiponectin levels are inversely associated with risk of obesity-related malignancies [5–7]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.