ADIPOR1 and ADIPOR2 mediate the link between adiponectin and activation of AMP-activated protein kinase, which causes adiponectin to exert anti-proliferative effects under cancer conditions [8].The ADIPOR1 SNP rs1342387(G/A)may modulate the effects of adiponectin on cancer risk by regulating the expression of adiponectin receptors, but our results suggest that this is not necessarily true in all cancers and all ethnicities. Here, ADIPOR1 is linked to cancer.