The young, obese Ossabaw mini-pig demonstrates many of the reproductive pathologies seen in obese women including an extended cycle length, hyperandrogenism, decreased LH, and aberrant steroidogenesis, supporting the potential use of the obese Ossabaw mini-pig as a model in which to study the effects of obesity on ovarian dysfunction. The gene discussed is PLOD1; the disease is obesity due to melanocortin 4 receptor deficiency.