Several of the identified targets genes are known mediators of prostate cancer cell “stemness” and self-renewal, such as NKx3.1 [24], BMI-1 [23], and SOX-4 [25]; some are also embryonic stem cell (ESC) regulators, such as KLF4 and SOX2 [40]. This evidence concerns the gene NKX3-1 and Familial prostate cancer.