Consistent with our proposed mechanism of action that involves an enhanced activation of the TSP-1/CD36 axis under TAX2 treatment, these experimental data are also coherent with previous work underlying the anti-angiogenic and anti-tumor potential of the CD36-binding 3TSR module of TSP-1 in human pancreatic cancer models [51, 52]. Here, THBS1 is linked to familial pancreatic carcinoma.