ERBB2 and breast cancer: In summary, this study demonstrates that a proportion of TNBC is associated with hypoxia-related markers, that this association is not exclusive to TNBC but equally, if not more prominently, present in other breast cancer subtypes such as the HER2+ tumors, and finally that the presence of central fibrosis and necrosis correlate with higher HIF-1α expression levels in the studied cases.