Under hypoxic conditions, the induced “angiogenic switch” causes an elevated expression of Hypoxia inducible factor 1α(HIF-1α) [1–3], followed by “vascular endothelial growth factor (VEGF)-induced angiogenesis”, and consequently tumor vascularization[4], which promotes tumor progression, invasion and eventually metastasis[5–7]. Here, HIF1A is linked to neoplasm.